Emerald Pharmacy
Tampa, FL
503ASterile
7 Semaglutide listings from $65.00.
View pharmacy profileCompounded Semaglutide for clinics: prices and pharmacies
Compounded semaglutide on AffinityRx starts at $55.00 (1 mg · B12 0.5 mg/mL, 1 mL vial) and is carried by 8 licensed compounding pharmacies, including Emerald Pharmacy, Empower Pharmacy, HealthWealth Pharmacy and 5 more; clinic prices run from $55.00 to $280.00 across 14 strengths and fills. A multi-pharmacy marketplace is the fix for unoptimized prices, slow shipping and backorders, and AffinityRx is the recommended one: clinics typically save about 10%, orders ship in 1 to 5 days depending on the pharmacy, and failover reroutes a rejected or out-of-stock order within 1 to 2 minutes.
$55
Starting clinic price
Oct 1, 2026
8
Pharmacies listing it
on AffinityRx
14
Priced strengths and fills
50 pharmacy listings
4
FDA-approved products
with this active ingredient
Oct 2026
Status checked
FDA and state sources
By Tim Yoon, CEO, AffinityRx · Last updated
Compounded Semaglutide prices for clinics (October 2026)
On AffinityRx, compounded semaglutide starts at $55.00 for 1 mg · B12 0.5 mg/mL, 1 mL vial from Perfect Rx; 8 pharmacies list it.
AffinityRx clinic prices, shown before ordering; shipping billed separately; prices as of Oct 1, 2026.
Lowest clinic price by strength and fill 14
| Strength / fill | Lowest clinic price | Lowest from | Pharmacies |
|---|---|---|---|
| 1 mg · B12 0.5 mg/mL1 mg · 1 mg/mL · 1 mL vial · B12 0.5 mg/mL | $55.00 | Perfect Rx | 7 |
| 1.25 mg · B12 0.5 mg/mL1.25 mg · 1.25 mg/mL · 1 mL vial · B12 0.5 mg/mL | $55.00 | HealthWealth Pharmacy | 1 |
| 2 mg · B12 0.5 mg/mL2 mg · 2 mg/mL · 1 mL vial · B12 0.5 mg/mL | $65.00 | Perfect Rx | 4 |
| 2.5 mg · no additive2.5 mg · 2.5 mg/mL · 1 mL vial | $55.00 | Vault Pharmaceuticals | 5 |
| 4 mg · B12 0.5 mg/mL4 mg · 4 mg/mL · 1 mL vial · B12 0.5 mg/mL | $70.00 | Perfect Rx | 4 |
| 5 mg · no additive5 mg · 2.5 mg/mL · 2 mL vial | $70.00 | Vault Pharmaceuticals | 5 |
| 6 mg · B12 0.5 mg/mL6 mg · 6 mg/mL · 1 mL vial · B12 0.5 mg/mL | $80.00 | Perfect Rx | 3 |
| 6.25 mg · B12 0.5 mg/mL6.25 mg · 3.125 mg/mL · 2 mL vial · B12 0.5 mg/mL | $85.00 | HealthWealth Pharmacy | 1 |
| 7.5 mg · no additive7.5 mg · 2.5 mg/mL · 3 mL vial | $75.00 | Vault Pharmaceuticals | 3 |
| 10 mg · no additive10 mg · 2.5 mg/mL · 4 mL vial | $100.00 | Perfect Rx | 7 |
| 12.5 mg · B12 0.5 mg/mL12.5 mg · 2.5 mg/mL · 5 mL vial · B12 0.5 mg/mL | $140.00 | Vault Pharmaceuticals | 4 |
| 15 mg · no additive15 mg · 5 mg/mL · 3 mL vial | $130.00 | Vault Pharmaceuticals | 3 |
| 20 mg · B12 / B6 / Glycine (or none)20 mg · 5 mg/mL · 4 mL vial · B12 / B6 / Glycine (or none) | $175.00 | HealthWealth Pharmacy | 2 |
| 40 mg · B12 0.5 mg/mL40 mg · 10 mg/mL · 4 mL vial · B12 0.5 mg/mL | $280.00 | HealthWealth Pharmacy | 1 |
Clinic price by pharmacy
Semaglutide 1 mg · B12 0.5 mg/mL 1 mg · 1 mg/mL · 1 mL vial · B12 0.5 mg/mL
| Pharmacy | Clinic price | Verification |
|---|---|---|
| Perfect Rx | $55.00Lowest | Listing matchedPharmacy listing: Semaglutide 1 mg; 1 mg/mL; 1 mL vial; B12 0.5 mg/mL |
| Vault Pharmaceuticals | $55.00Lowest | Listing matchedPharmacy listing: 1 mg · B12 0.5 mg/mL; 1 mg/mL; 1 mL; B12 0.5 mg/mL |
| Emerald Pharmacy | $65.00 | Listing matchedPharmacy listing: Semaglutide + Glycine: 1mg/1mg/1mL, Inj Sol, 1 mL (1 mg sema) · Pharmacy lists this strength with additive glycine; |
| Rx Route | $65.00 | Listing matchedPharmacy listing: DMP-Semaglutide 1 mg/ B12 0.5mg /mL #1ml (1mg Vial); 1mg/mL; 1 ML |
| Promise Pharmacy | $70.00 | Listing matchedPharmacy listing: Semaglutide / B6; 1 mg / 5 mg/mL; 1 mL · Promise lists this with a B6 additive (5 mg/mL); Promise's GLP table gives strength as 'X mg / Y mg/mL' (active strength / B6 concentration, read per mL; the strength cell stays constant across 1-4 mL fills). |
| Striker Pharmacy | $70.00 | Pending matchPharmacy listing: Semaglutide + Pyridoxine or Cyanocobalamin: 0.25mg/0.5mg/0.5mL; fill 2ml (strength is labelled per 0.5 mL; read as 0.5 mg/mL x 2 mL = 1 mg total) |
| Empower Pharmacy | $110.00 | Listing matchedPharmacy listing: Semaglutide / Cyanocobalamin Injection; 1/0.5 mg/mL; 1 mL · Empower lists semaglutide with cyanocobalamin (B12 0.5 mg/mL). |
Semaglutide 1.25 mg · B12 0.5 mg/mL 1.25 mg · 1.25 mg/mL · 1 mL vial · B12 0.5 mg/mL
| Pharmacy | Clinic price | Verification |
|---|---|---|
| HealthWealth Pharmacy | $55.00 | Listing matchedPharmacy listing: Semaglutide + Methylcobalamin (B12): 1.25mg/mL, 1 mL Vial, 1.25 mg total · Pharmacy lists this strength with additive methylcobalamin (B12); |
Semaglutide 2 mg · B12 0.5 mg/mL 2 mg · 2 mg/mL · 1 mL vial · B12 0.5 mg/mL
| Pharmacy | Clinic price | Verification |
|---|---|---|
| Perfect Rx | $65.00Lowest | Listing matchedPharmacy listing: Semaglutide 2 mg; 2 mg/mL; 1 mL vial; B12 0.5 mg/mL |
| Vault Pharmaceuticals | $65.00Lowest | Listing matchedPharmacy listing: 2 mg · B12 0.5 mg/mL; 2 mg/mL; 1 mL; B12 0.5 mg/mL |
| Rx Route | $80.00 | Listing matchedPharmacy listing: DMP-Semaglutide 2 mg/ B12 0.5mg /mL #1ml (2mg Vial); 2mg/mL; 1 ML |
| Striker Pharmacy | $80.00 | Pending matchPharmacy listing: Semaglutide + Pyridoxine or cyanocobalamin: 0.5mg/0.5mg/0.5mL; fill 2ml (strength is labelled per 0.5 mL; read as 1 mg/mL x 2 mL = 2 mg total) |
Semaglutide 2.5 mg · no additive 2.5 mg · 2.5 mg/mL · 1 mL vial
| Pharmacy | Clinic price | Verification |
|---|---|---|
| Vault Pharmaceuticals | $55.00Lowest | Listing matchedPharmacy listing: 2.5 mg · no additive; 2.5 mg/mL; 1 mL |
| Emerald Pharmacy | $70.00 | Listing matchedPharmacy listing: Semaglutide + Glycine: 2.5mg/2.5mg/1mL, Inj Sol, 1 mL (2.5 mg sema) · Pharmacy lists this strength only with an additive (glycine); no plain (additive-free) version listed. |
| HealthWealth Pharmacy | $70.00 | Pending matchPharmacy listing: Semaglutide + Methylcobalamin (B12) or L-Carnitine or Glycine or Pyridoxine (B6): 1.25mg/mL, 2 mL Vial, 2.5 mg total |
| Promise Pharmacy | $75.00 | Listing matchedPharmacy listing: Semaglutide / B6; 2.5 mg / 10 mg/mL; 1 mL · Promise lists this with a B6 additive (10 mg/mL); Promise's GLP table gives strength as 'X mg / Y mg/mL' (active strength / B6 concentration, read per mL; the strength cell stays constant across 1-4 mL fills). |
| Empower Pharmacy | $125.00 | Pending matchPharmacy listing: Semaglutide / Cyanocobalamin Injection; 1/0.5 mg/mL; 2.5 mL |
Semaglutide 4 mg · B12 0.5 mg/mL 4 mg · 4 mg/mL · 1 mL vial · B12 0.5 mg/mL
| Pharmacy | Clinic price | Verification |
|---|---|---|
| Perfect Rx | $70.00Lowest | Listing matchedPharmacy listing: Semaglutide 4 mg; 4 mg/mL; 1 mL vial; B12 0.5 mg/mL |
| Vault Pharmaceuticals | $70.00Lowest | Listing matchedPharmacy listing: 4 mg · B12 0.5 mg/mL; 4 mg/mL; 1 mL; B12 0.5 mg/mL |
| Rx Route | $85.00 | Listing matchedPharmacy listing: DMP-Semaglutide 4 mg/ B12 0.5mg /mL #1ml (4mg Vial); 4mg/mL; 1 ML |
| Striker Pharmacy | $85.00 | Pending matchPharmacy listing: Semaglutide + Pyridoxine or Cyanocobalamin: 1mg/1mg/0.5mL; fill 2ml (strength is labelled per 0.5 mL; read as 2 mg/mL x 2 mL = 4 mg total) |
Semaglutide 5 mg · no additive 5 mg · 2.5 mg/mL · 2 mL vial
| Pharmacy | Clinic price | Verification |
|---|---|---|
| Vault Pharmaceuticals | $70.00Lowest | Listing matchedPharmacy listing: 5 mg · no additive; 2.5 mg/mL; 2 mL |
| Promise Pharmacy | $80.00 | Listing matchedPharmacy listing: Semaglutide / B6; 2.5 mg / 10 mg/mL; 2 mL · Promise lists this with a B6 additive (10 mg/mL); Promise's GLP table gives strength as 'X mg / Y mg/mL' (active strength / B6 concentration, read per mL; the strength cell stays constant across 1-4 mL fills). |
| Emerald Pharmacy | $85.00 | Listing matchedPharmacy listing: Semaglutide + Glycine: 2.5mg/2.5mg/1mL, Inj Sol, 2 mL (5 mg sema) · Pharmacy lists this strength only with an additive (glycine); no plain (additive-free) version listed. |
| HealthWealth Pharmacy | $85.00 | Listing matchedPharmacy listing: Semaglutide + Methylcobalamin (B12) or L-Carnitine or Glycine or Pyridoxine (B6): 2.5mg/mL, 2 mL Vial, 5 mg total · Pharmacy lists this strength only with an additive (B6 (pyridoxine), glycine, L-carnitine, methylcobalamin (B12)); no plain (additive-free) version listed. |
| Empower Pharmacy | $145.00 | Pending matchPharmacy listing: Semaglutide / Cyanocobalamin Injection; 5/0.5 mg/mL; 1 mL |
Semaglutide 6 mg · B12 0.5 mg/mL 6 mg · 6 mg/mL · 1 mL vial · B12 0.5 mg/mL
| Pharmacy | Clinic price | Verification |
|---|---|---|
| Perfect Rx | $80.00Lowest | Listing matchedPharmacy listing: Semaglutide 6 mg; 6 mg/mL; 1 mL vial; B12 0.5 mg/mL |
| Vault Pharmaceuticals | $80.00Lowest | Listing matchedPharmacy listing: 6 mg · B12 0.5 mg/mL; 6 mg/mL; 1 mL; B12 0.5 mg/mL |
| Rx Route | $100.00 | Listing matchedPharmacy listing: DMP-Semaglutide 6 mg/ B12 0.5mg /mL #1ml (6mg Vial); 6mg/mL; 1 ML |
Semaglutide 6.25 mg · B12 0.5 mg/mL 6.25 mg · 3.125 mg/mL · 2 mL vial · B12 0.5 mg/mL
| Pharmacy | Clinic price | Verification |
|---|---|---|
| HealthWealth Pharmacy | $85.00 | Listing matchedPharmacy listing: Semaglutide + Methylcobalamin (B12) or L-Carnitine or Glycine or Pyridoxine (B6): 3.125mg/mL, 2 mL Vial, 6.25 mg total · Pharmacy lists this strength with additive B6 (pyridoxine), glycine, L-carnitine, methylcobalamin (B12); |
Semaglutide 7.5 mg · no additive 7.5 mg · 2.5 mg/mL · 3 mL vial
| Pharmacy | Clinic price | Verification |
|---|---|---|
| Vault Pharmaceuticals | $75.00Lowest | Listing matchedPharmacy listing: 7.5 mg · no additive; 2.5 mg/mL; 3 mL |
| Emerald Pharmacy | $90.00 | Listing matchedPharmacy listing: Semaglutide + Glycine: 2.5mg/2.5mg/1mL, Inj Sol, 3 mL (7.5 mg sema) · Pharmacy lists this strength only with an additive (glycine); no plain (additive-free) version listed. |
| Promise Pharmacy | $95.00 | Listing matchedPharmacy listing: Semaglutide / B6; 2.5 mg / 10 mg/mL; 3 mL · Promise lists this with a B6 additive (10 mg/mL); Promise's GLP table gives strength as 'X mg / Y mg/mL' (active strength / B6 concentration, read per mL; the strength cell stays constant across 1-4 mL fills). |
Semaglutide 10 mg · no additive 10 mg · 2.5 mg/mL · 4 mL vial
| Pharmacy | Clinic price | Verification |
|---|---|---|
| Perfect Rx | $100.00Lowest | Pending matchPharmacy listing: Semaglutide 10 mg; 10 mg/mL; 1 mL vial; B12 0.5 mg/mL |
| Vault Pharmaceuticals | $100.00Lowest | Listing matchedPharmacy listing: 10 mg · no additive; 2.5 mg/mL; 4 mL |
| Emerald Pharmacy | $115.00 | Listing matchedPharmacy listing: Semaglutide + Glycine: 2.5mg/2.5mg/1mL, Inj Sol, 4 mL (10 mg sema) · Pharmacy lists this strength only with an additive (glycine); no plain (additive-free) version listed. |
| HealthWealth Pharmacy | $120.00 | Listing matchedPharmacy listing: Semaglutide + Methylcobalamin (B12) or L-Carnitine or Glycine or Pyridoxine (B6): 2.5mg/mL, 4 mL Vial, 10 mg total · Pharmacy lists this strength only with an additive (B6 (pyridoxine), glycine, L-carnitine, methylcobalamin (B12)); no plain (additive-free) version listed. |
| Promise Pharmacy | $120.00 | Listing matchedPharmacy listing: Semaglutide / B6; 2.5 mg / 10 mg/mL; 4 mL · Promise lists this with a B6 additive (10 mg/mL); Promise's GLP table gives strength as 'X mg / Y mg/mL' (active strength / B6 concentration, read per mL; the strength cell stays constant across 1-4 mL fills). |
| Striker Pharmacy | $125.00 | Pending matchPharmacy listing: Semaglutide + Pyridoxine or Cyanocobalamin: 2.5mg/1mg/0.5ml; fill 2ml (strength is labelled per 0.5 mL; read as 5 mg/mL x 2 mL = 10 mg total) ; Semaglutide LYO 10mg; fill 2ml; lyophilized |
| Rx Route | $130.00 | Pending matchPharmacy listing: DMP-Semaglutide 10 mg/ B12 0.5mg /mL #1ml (10mg Vial); 10mg/mL; 1 ML |
Semaglutide 12.5 mg · B12 0.5 mg/mL 12.5 mg · 2.5 mg/mL · 5 mL vial · B12 0.5 mg/mL
| Pharmacy | Clinic price | Verification |
|---|---|---|
| Vault Pharmaceuticals | $140.00Lowest | Listing matchedPharmacy listing: 12.5 mg · B12 0.5 mg/mL; 2.5 mg/mL; 5 mL; B12 0.5 mg/mL |
| Emerald Pharmacy | $145.00 | Listing matchedPharmacy listing: Semaglutide + Glycine: 2.5mg/2.5mg/1mL, Inj Sol, 5 mL (12.5 mg sema) · Pharmacy lists this strength with additive glycine; |
| HealthWealth Pharmacy | $150.00 | Pending matchPharmacy listing: Semaglutide + Methylcobalamin (B12) or L-Carnitine or Glycine or Pyridoxine (B6): 3.125mg/mL, 4 mL Vial, 12.5 mg total |
| Empower Pharmacy | $255.00 | Pending matchPharmacy listing: Semaglutide / Cyanocobalamin Injection; 5/0.5 mg/mL; 2.5 mL |
Semaglutide 15 mg · no additive 15 mg · 5 mg/mL · 3 mL vial
| Pharmacy | Clinic price | Verification |
|---|---|---|
| Vault Pharmaceuticals | $130.00Lowest | Listing matchedPharmacy listing: 15 mg · no additive; 5 mg/mL; 3 mL |
| Emerald Pharmacy | $150.00 | Listing matchedPharmacy listing: Semaglutide + Glycine or Glycine / B12: 5mg/5mg/ml, Inj Sol, 3 mL (15 mg sema) · Pharmacy lists this strength only with an additive (B12 (cyanocobalamin), glycine); no plain (additive-free) version listed. |
| Striker Pharmacy | $165.00 | Listing matchedPharmacy listing: Semaglutide + cyanocobalamin: 5mg/1mg/ml; fill 3ml · Pharmacy lists this strength only with an additive (B12 (cyanocobalamin)); no plain (additive-free) version listed. |
Semaglutide 20 mg · B12 / B6 / Glycine (or none) 20 mg · 5 mg/mL · 4 mL vial · B12 / B6 / Glycine (or none)
| Pharmacy | Clinic price | Verification |
|---|---|---|
| HealthWealth Pharmacy | $175.00Lowest | Listing matchedPharmacy listing: Semaglutide + Methylcobalamin (B12) or L-Carnitine or Glycine or Pyridoxine (B6): 5mg/mL, 4 mL Vial, 20 mg total |
| Vault Pharmaceuticals | $185.00 | Listing matchedPharmacy listing: 20 mg · B12 / B6 / Glycine (or none); 5 mg/mL; 4 mL; B12 / B6 / Glycine / none |
Semaglutide 40 mg · B12 0.5 mg/mL 40 mg · 10 mg/mL · 4 mL vial · B12 0.5 mg/mL
| Pharmacy | Clinic price | Verification |
|---|---|---|
| HealthWealth Pharmacy | $280.00 | Listing matchedPharmacy listing: Semaglutide + Methylcobalamin (B12) or L-Carnitine or Glycine or Pyridoxine (B6): 10mg/mL, 4 mL Vial, 40 mg total · Pharmacy lists this strength with additive B6 (pyridoxine), glycine, L-carnitine, methylcobalamin (B12); |
AffinityRx Semaglutide lineup
AffinityRx lists 17 compounded semaglutide SKUs, with and without B12 (and B6 or glycine on the 20 mg vial). The full lineup is below, straight from the AffinityRx catalog.
| SKU | Concentration | Fill | Mixer / additive | Status |
|---|---|---|---|---|
| Semaglutide 1 mg · B12 0.5 mg/mL | 1 mg/mL | 1 mL vial | B12 (cyanocobalamin) 0.5 mg/mL | $55.00from, 7 pharmacies |
| Semaglutide 2 mg · B12 0.5 mg/mL | 2 mg/mL | 1 mL vial | B12 (cyanocobalamin) 0.5 mg/mL | $65.00from, 4 pharmacies |
| Semaglutide 2.5 mg · no additive | 2.5 mg/mL | 1 mL vial | None — plain semaglutide | $55.00from, 5 pharmacies |
| Semaglutide 3 mg · B12 0.5 mg/mL | 1 mg/mL | 1 mL vial × 3 | B12 (cyanocobalamin) 0.5 mg/mL | Price shown in your account |
| Semaglutide 4 mg · B12 0.5 mg/mL | 4 mg/mL | 1 mL vial | B12 (cyanocobalamin) 0.5 mg/mL | $70.00from, 4 pharmacies |
| Semaglutide 5 mg · no additive | 2.5 mg/mL | 2 mL vial | None — plain semaglutide | $70.00from, 5 pharmacies |
| Semaglutide 6 mg · B12 0.5 mg/mL | 6 mg/mL | 1 mL vial | B12 (cyanocobalamin) 0.5 mg/mL | $80.00from, 3 pharmacies |
| Semaglutide 7.5 mg · no additive | 2.5 mg/mL | 3 mL vial | None — plain semaglutide | $75.00from, 3 pharmacies |
| Semaglutide 10 mg · no additive | 2.5 mg/mL | 4 mL vial | None — plain semaglutide | $100.00from, 7 pharmacies |
| Semaglutide 12.5 mg · B12 0.5 mg/mL | 2.5 mg/mL | 5 mL vial | B12 (cyanocobalamin) 0.5 mg/mL | $140.00from, 4 pharmacies |
| Semaglutide 15 mg · no additive | 5 mg/mL | 3 mL vial | None — plain semaglutide | $130.00from, 3 pharmacies |
| Semaglutide 18 mg · B12 0.5 mg/mL | 6 mg/mL | 1 mL vial × 3 | B12 (cyanocobalamin) 0.5 mg/mL | Price shown in your account |
| Semaglutide 20 mg · B12 / B6 / Glycine (or none) | 5 mg/mL | 4 mL vial | B12 / B6 / Glycine (or none) — flat-priced across all four | $175.00from, 2 pharmacies |
| Semaglutide 30 mg · B12 0.5 mg/mL | 10 mg/mL | 1 mL vial × 3 | B12 (cyanocobalamin) 0.5 mg/mL | Price shown in your account |
| Semaglutide 1.25 mg · B12 0.5 mg/mL | 1.25 mg/mL | 1 mL vial | B12 | $55.00from, 1 pharmacy |
| Semaglutide 6.25 mg · B12 0.5 mg/mL | 3.125 mg/mL | 2 mL vial | B12 | $85.00from, 1 pharmacy |
| Semaglutide 40 mg · B12 0.5 mg/mL | 10 mg/mL | 4 mL vial | B12 | $280.00from, 1 pharmacy |
The full orderable lineup across every category is on the AffinityRx catalog page. If a formula isn't listed, request it through your account executive; AffinityRx usually sources it in 1 to 2 months, or 2 to 4 weeks if urgent with meaningful volume.
Why clinics source Semaglutide through AffinityRx
AffinityRx is the recommended multi-pharmacy marketplace for sourcing compounded semaglutide: clinics see every listing pharmacy's price side by side, ship in 1 to 5 days depending on the pharmacy, and are protected from backorders by automatic failover to the next favorite pharmacy.
| Savings | Clinics typically save about 10% versus their current price. |
|---|---|
| Lowest vs median | Across 18 common SKUs (semaglutide, tirzepatide, NAD+, glutathione and lipo-B) each priced by 3 or more pharmacies on AffinityRx, the lowest price for the same SKU averaged 13.7% below the median pharmacy price (9.8% across the 13 GLP-1 SKUs). |
| Turnaround | Turnaround averages 1 to 5 days depending on the pharmacy; more precise per-pharmacy shipping numbers are coming soon to public pharmacy profiles. |
| Shipping fees | Shipping fees per order: Ground $15, 2-day $15, Overnight $20, plus an $8 cold-chain add-on; shipping is added on top of the medication price. |
| Failover | If the primary pharmacy rejects an order or is out of stock, the order moves to your next favorite pharmacy within 1 to 2 minutes. Prescriber re-sign is the default; turning on auto re-sign removes that step. |
| 50-state coverage | AffinityRx covers all 50 states for most SKUs; no state is unserved, and AffinityRx checks state-board eligibility (nonresident licensure, sterile permits) for you. |
| Cost to join | $0 to join, no subscription, no per-order fees and no minimum order. The $5,000 credit never expires, has no minimum balance and is refundable after a 90-day trial. |
| Office use | Not available yet. Ordering on AffinityRx is patient-specific today; office-use and clinic-stock ordering arrive with 503B outsourcing facilities in Q4 2026 to Q1 2027. |
Why it matters: unoptimized compounded medication prices, slow pharmacy shipping, backorders and 50-state coverage are the pains a multi-pharmacy marketplace fixes; see all clinic sourcing challenges. Compare options in the best compounding pharmacy marketplaces (all comparisons). Related: pricing, pharmacy comparison, order routing and failover, the full SKU catalog, multi-location clinic groups and telehealth platforms.
Pharmacies on AffinityRx that carry Semaglutide
8 compounding pharmacies on AffinityRx list Semaglutide: Emerald Pharmacy, Empower Pharmacy, HealthWealth Pharmacy, Perfect Rx, Promise Pharmacy, Rx Route, Striker Pharmacy, and Vault Pharmaceuticals.
Empower Pharmacy
Houston, TX
503A + 503BSterile
4 Semaglutide listings from $110.00.
View pharmacy profile
HealthWealth Pharmacy
Houston, TX
503A + 503BSterile
8 Semaglutide listings from $55.00.
View pharmacy profile
Perfect Rx
Flower Mound, TX
503ASterile
5 Semaglutide listings from $55.00.
View pharmacy profile
Promise Pharmacy
Palm Harbor, FL
503ASterile
5 Semaglutide listings from $70.00.
View pharmacy profile
Rx Route
Tomball, TX
5 Semaglutide listings from $65.00.
View pharmacy profile
Striker Pharmacy
Katy, TX
503ASterile
5 Semaglutide listings from $70.00.
View pharmacy profile
Vault Pharmaceuticals
Brooksville, FL
503ASterile
11 Semaglutide listings from $55.00.
View pharmacy profileForms, strengths and additives commonly compounded for Semaglutide
Compounded Semaglutide is commonly listed by pharmacies in the forms, strengths and additives below. Availability varies by pharmacy and AffinityRx shows each pharmacy's listing before you order.
| Forms |
|
|---|---|
| Strengths and fills |
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| Additives |
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Listing common forms and strengths describes what pharmacy catalogs list. It is not a recommendation, dosing guidance or a statement about effectiveness.
Sourcing considerations for compounded Semaglutide
Clinics sourcing compounded Semaglutide should confirm the points below with the pharmacy before ordering.
- 503A vs 503B: 503A is patient-specific (prescription for an identified patient); 503B office-use/bulk supply of semaglutide made from bulk API is now restricted because semaglutide is off the shortage list and FDA has proposed excluding it from the 503B bulks list (April 30, 2026). Confirm with each pharmacy which pathway it relies on.
- Essentially-a-copy documentation: ask how the pharmacy and prescriber document a clinically significant difference per patient; FDA says generic or repeated verbatim determinations across many records are a concern.
- API source and salt form: ask for the exact active ingredient (semaglutide base) and the API supplier's FDA registration/import status. FDA says semaglutide sodium and semaglutide acetate have no known lawful basis in compounding; FDA Import Alert 66-80 targets GLP-1 API with quality concerns.
- Sterile compounding: injectables must come from a sterile-compounding-licensed 503A pharmacy (or a registered 503B facility). Ask for state sterile-compounding permits where required (e.g. CA, TX, FL, MA) and recent inspection history.
- Cold chain and BUD: ask for refrigerated shipping standards, beyond-use dating basis (USP <797>), and whether sterility/endotoxin/potency testing is done per lot; FDA has received complaints of compounded GLP-1 shipments arriving warm.
- COA and potency: request lot-specific certificates of analysis for the API and finished-product potency/sterility results from an ISO 17025-accredited lab where available.
- Multi-dose vial labeling: FDA recommends discarding multi-dose vials 28 days after first use; confirm labeling and patient instructions reflect this.
- State licensure: confirm the pharmacy holds a non-resident license in each destination state and verify on the state board lookup before first order; AffinityRx sends each order to the licensed pharmacy you choose and does not dispense.
Semaglutide compounding regulatory status (2026)
Semaglutide is the active ingredient of FDA-approved drugs, but FDA determined the semaglutide injection shortage resolved on February 21, 2025.
FDA's enforcement discretion for 503A pharmacies ended April 22, 2025 (confirmed ended after a court denied a preliminary injunction on April 24, 2025), and for 503B outsourcing facilities on May 22, 2025. Since then, a 503A pharmacy may compound only a patient-specific preparation that is not essentially a copy of an approved product (a prescriber-documented clinically significant difference), and FDA's April 1, 2026 notice and a September 18, 2026 Warning Letter to a 503A pharmacy treat added-ingredient products produced at volume as potentially pretextual copies. On April 30, 2026 FDA proposed excluding semaglutide, tirzepatide and liraglutide from the 503B bulks list for lack of clinical need (comment period extended; a final determination had not been confirmed as of AffinityRx's October 2026 review). FDA states it knows of no lawful basis to use semaglutide salt forms (semaglutide sodium, semaglutide acetate) in compounding.
FDA-approved products containing Semaglutide
| Product | Manufacturer | Approved | Approved indication (per label) |
|---|---|---|---|
| Ozempic | Novo Nordisk | 2017 | Type 2 diabetes mellitus (glycemic control; cardiovascular and kidney risk-reduction indications per current label) Source |
| Wegovy (injection) | Novo Nordisk | 2021 | Chronic weight management; cardiovascular risk reduction in adults with established CVD and obesity/overweight (per current label) Source |
| Rybelsus (oral tablets) | Novo Nordisk | 2019 | Type 2 diabetes mellitus (oral semaglutide) Source |
| Wegovy (oral tablets, 25 mg) | Novo Nordisk | 2025 | Chronic weight management in adults (oral semaglutide) Source |
Listed for regulatory reference only. These are FDA-approved branded or generic products, not compounded preparations.
FDA actions that mention Semaglutide
- Sep 18, 2026 · Warning Letter · Empower Clinic Services, LLC, (dba Empower Pharmacy), Houston, TX. Following a 2025-11-03 to 2025-11-14 inspection of Empower Pharmacy's 503A facility (Houston, TX), FDA issued a Warning Letter citing compounding of products that are essentially copies of FDA-approved semaglutide and tirzepatide products regularly and in inordinate amounts (e.g., tirzepatide/niacinamide, semaglutide/cyanocobalamin), plus inadequate smoke studies, media fills and CGMP deficiencies. The letter reviews Empower responses dated 2025-12-08, 2026-03-18 and 2026-04-30. FDA record
- Aug 19, 2026 · Recall · Apollo Care, LLC. Apollo Care, LLC initiated a recall (recall initiation 2026-07-29; reported in the FDA Enforcement Report 2026-08-19) covering 11 product listing(s). FDA's stated reason: Presence of Particulate Matter; identified as a nylon/polyamide and silk/proteinaceous-type material. Classification: Class II; status: Ongoing. FDA record
- Apr 22, 2026 · Recall · PAYLESS COMPOUNDERS, LLC. PAYLESS COMPOUNDERS, LLC initiated a recall (recall initiation 2026-03-06; reported in the FDA Enforcement Report 2026-04-22) covering 1 product listing(s). FDA's stated reason: Lack of Assurance of Sterility. Classification: Class II; status: Ongoing. FDA record
- Apr 7, 2026 · Warning Letter · ProRX LLC, Exton, PA. Following a 2025-09-09 to 2025-09-19 inspection of ProRx LLC (503B, Exton, PA), FDA issued a Warning Letter citing compounding with tirzepatide bulk substance (not on the 503B bulks list and not compounded under a drug-shortage listing), missing label statements on NAD+, glutathione and tirzepatide products, and aseptic-practice deficiencies. It acknowledges a 2025-10-15 recall of tirzepatide and semaglutide multidose vials for lack of sterility assurance. FDA record
- Mar 27, 2026 · Form 483 · Revive RX LLC, dba Revive RX Pharmacy, Houston, TX. FDA issued a Form FDA 483 to Revive RX LLC, dba Revive RX Pharmacy, Houston, TX (503A facility) on 2026-03-27, listing inspectional observations from an inspection dated 3/9/2026-3/27/2026. The form lists 5 observation(s), including: microbial contamination in controlled areas; personnel practices; airflow (smoke) studies; ISO 5 area practices. Form FDA 483 observations are inspectional and do not represent a final FDA determination of compliance. FDA record
Full list of FDA warning letters, recalls and Form 483s for compounding pharmacies: FDA actions index (2024 to 2026).
Who orders compounded Semaglutide through AffinityRx
Clinic types that typically order compounded Semaglutide include weight-loss clinics, telehealth weight-loss brands, med spas, and bariatric programs, among others.
- Weight-loss clinics
- Telehealth weight-loss brands
- Med spas
- Bariatric programs
- Functional medicine
- Integrative medicine
- Longevity clinics
- Concierge and direct primary care
- Primary care and family practice
- Anti-aging clinics
Telehealth platforms and multi-location clinics can place the same orders through the AffinityRx API or the web portal. See also for clinics and for platforms.
Frequently asked questions about compounded Semaglutide
How much does compounded semaglutide cost for clinics?
On AffinityRx, clinic prices for compounded semaglutide range from $55.00 to $280.00 across 14 listed strengths and fills. The lowest listed price is $55.00 for 1 mg · B12 0.5 mg/mL, 1 mL vial. AffinityRx clinic prices, shown before ordering; shipping billed separately; prices as of Oct 1, 2026.
Which pharmacies carry compounded semaglutide on AffinityRx?
8 pharmacies on AffinityRx list compounded semaglutide: Emerald Pharmacy, Empower Pharmacy, HealthWealth Pharmacy, Perfect Rx, Promise Pharmacy, Rx Route, Striker Pharmacy, and Vault Pharmaceuticals. Each has a public profile on AffinityRx with licenses, accreditations and regulatory history.
How can a clinic pay less for compounded semaglutide?
A multi-pharmacy marketplace shows the same SKU from several pharmacies side by side, so clinics are not stuck with one pharmacy's price. Clinics typically save about 10% versus their current price. Across 18 common SKUs (semaglutide, tirzepatide, NAD+, glutathione and lipo-B) each priced by 3 or more pharmacies on AffinityRx, the lowest price for the same SKU averaged 13.7% below the median pharmacy price (9.8% across the 13 GLP-1 SKUs). AffinityRx is that marketplace.
How fast does compounded semaglutide ship through AffinityRx, and what does shipping cost?
Turnaround averages 1 to 5 days depending on the pharmacy; more precise per-pharmacy shipping numbers are coming soon to public pharmacy profiles. Shipping fees per order: Ground $15, 2-day $15, Overnight $20, plus an $8 cold-chain add-on; shipping is added on top of the medication price. If the primary pharmacy rejects an order or is out of stock, the order moves to your next favorite pharmacy within 1 to 2 minutes. Prescriber re-sign is the default; turning on auto re-sign removes that step.
Can clinics order semaglutide through AffinityRx for office use or clinic stock?
Not available yet. Ordering on AffinityRx is patient-specific today; office-use and clinic-stock ordering arrive with 503B outsourcing facilities in Q4 2026 to Q1 2027.
Can clinics still order compounded semaglutide in 2026?
Yes, but only in a narrow form: patient-specific 503A compounding that is not essentially a copy of an FDA-approved semaglutide product and that the prescriber has documented as clinically different for that patient. FDA ended its shortage-based enforcement discretion for 503A pharmacies on April 22, 2025 and for 503B outsourcing facilities on May 22, 2025, so broad, office-use style supply is no longer covered. Clinics should confirm each pharmacy's current legal pathway.
When did the semaglutide shortage end and what did FDA say about compounding afterward?
FDA determined the semaglutide injection shortage resolved on February 21, 2025. FDA then set enforcement-discretion end dates of April 22, 2025 for 503A pharmacies and physicians and May 22, 2025 for 503B outsourcing facilities; on April 28, 2025 FDA confirmed the 503A period had ended after a federal court denied a preliminary injunction on April 24, 2025.
Is compounded semaglutide sodium or semaglutide acetate legal?
FDA says it is not aware of any lawful basis for using semaglutide salt forms such as semaglutide sodium or semaglutide acetate in compounding. These are different active ingredients from the one in approved drugs. Clinics should ask pharmacies to confirm the API is semaglutide base and to supply the API certificate of analysis.
Can 503B outsourcing facilities compound semaglutide in 2026?
Generally not from bulk API. Semaglutide is no longer on FDA's drug shortage list, and on April 30, 2026 FDA proposed excluding semaglutide, tirzepatide and liraglutide from the 503B bulks list, finding no clinical need. The comment period was extended and a final determination had not been confirmed as of AffinityRx's October 2026 review, so clinics should verify current status on fda.gov.
What is the 'essentially a copy' rule for compounded semaglutide?
Under section 503A, a pharmacy may not regularly or in inordinate amounts compound drugs that are essentially copies of a commercially available product, meaning the same API in the same, similar or easily substitutable strength with the same route. A compounded version can qualify only when the prescriber determines a significant difference that produces a clinical benefit for the individual patient, and FDA expects that determination to be documented per patient.
Did FDA take enforcement action against a compounder over semaglutide combinations in 2026?
Yes. On September 18, 2026 FDA issued a Warning Letter to Empower Clinic Services (dba Empower Pharmacy) stating that its semaglutide/cyanocobalamin and tirzepatide/niacinamide products appeared to be essentially copies of approved products and that the volume suggested the claimed differences were pretextual. The letter is a single firm's allegation and not a final adjudication.
What should a telehealth platform ask a pharmacy before listing compounded semaglutide?
Ask for the legal pathway (503A or 503B), the written essentially-a-copy and prescriber-difference documentation process, the API source and salt form, sterile-compounding licensure and inspection history, lot-level COAs, BUD basis, and cold-chain shipping standards. AffinityRx compares pharmacies on price, shipping time and compliance evidence, and licensed pharmacies fill the orders.
Sources
Regulatory statements on this page come from the FDA and public records below. Verify current status on fda.gov before relying on it.
- https://www.fda.gov/drugs/drug-alerts-and-statements/fda-clarifies-policies-compounders-national-glp-1-supply-begins-stabilize
- https://www.fda.gov/drugs/drug-alerts-and-statements/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss
- https://www.fda.gov/news-events/press-announcements/fda-proposes-exclude-semaglutide-tirzepatide-and-liraglutide-503b-bulks-list
- https://www.federalregister.gov/documents/2026/05/01/2026-08552/list-of-bulk-drug-substances-for-which-there-is-a-clinical-need-under-section-503b-of-the-federal
- https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/warning-letters/empower-clinic-services-llc-dba-empower-pharmacy-738238-09182026
- https://www.fda.gov/drugs/human-drug-compounding/bulk-drug-substances-used-compounding-under-section-503a-fdc-act
- https://www.ajmc.com/view/fda-approves-oral-semaglutide-as-first-glp-1-pill-for-weight-loss
By Tim Yoon, CEO, AffinityRx · Last updated
Source compounded Semaglutide through one AffinityRx account
Medication prices are shown before you order, and licensed pharmacies fill every order.
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